Abstract Background Congenital myasthenic syndromes (CMS) are a heterogeneous group of inherited neuromuscular disorders sharing the common feature of fatigable weakness due to defective neuromuscular transmission.Despite rapidly increasing knowledge about the genetic origins, specific features and potential treatments for the known CMS entities, t
The extent of carbapenemase-encoding genes in public genome sequences
Genome sequences provide information on the genetic elements present in an organism, DEEP OCEAN MINERALS and currently there are databases containing hundreds of thousands of bacterial genome sequences.These repositories allow for mining patterns concerning antibiotic resistance gene occurrence in both pathogenic and non-pathogenic bacteria in e.g.
Recycled polymer: Green roads for polyester plastics
Plastics are integral Ice Bucket to numerous significant social advancements.Nonetheless, their contribution to environmental pollution and climate crises cannot be disregarded, as their negative impact on the environment increases with incremental production capacity and demand.Concerted global action is urgently required to promote the green recy
SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data
Abstract Solid tumors are spatially heterogeneous in their Ostomy Creams genetic, molecular, and cellular composition, but recent spatial profiling studies have mostly charted genetic and RNA variation in tumors separately.To leverage the potential of RNA to identify copy number alterations (CNAs), we develop SlideCNA, a computational tool to extra